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The most common and effective treatments for depression are psychotherapy, medication, and electroconvulsive therapy (ECT); a combination of treatments is the most effective approach when depression is resistant to treatment.<ref name= Karrouri2021>{{cite journal |vauthors=Karrouri R, Hammani Z, Benjelloun R, Otheman Y |title=Major depressive disorder: Validated treatments and future challenges |journal=World J Clin Cases |volume=9 |issue=31 |pages=9350–9367 |date=November 2021 |pmid=34877271 |pmc=8610877 |doi=10.12998/wjcc.v9.i31.9350 |type=Review |doi-access=free }}</ref> [[American Psychiatric Association]] treatment guidelines recommend that initial treatment should be individually tailored based on factors including severity of symptoms, co-existing disorders, prior treatment experience, and personal preference. Options may include pharmacotherapy, psychotherapy, exercise, ECT, [[transcranial magnetic stimulation]] (TMS) or [[light therapy]]. [[Antidepressant]] medication is recommended as an initial treatment choice in people with mild, moderate, or severe major depression, and should be given to all people with severe depression unless ECT is planned.<ref name=apaguidelines/> There is evidence that collaborative care by a team of health care practitioners produces better results than routine single-practitioner care.<ref>{{cite journal | vauthors = Archer J, Bower P, Gilbody S, et al| title = Collaborative care for depression and anxiety problems | journal = The Cochrane Database of Systematic Reviews | volume = 2012 | page = CD006525 | date = October 2012 | issue = 10 | pmid = 23076925 | doi = 10.1002/14651858.CD006525.pub2 | pmc = 11627142 | hdl = 10871/13751 | hdl-access = free }}</ref>
Psychotherapy is the treatment of choice (over medication) for people under 18,<ref name=
:* People with a history of moderate or severe depression
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